[甲氨蝶呤/5-氟尿嘧啶疗法用于治疗伴有腹膜转移的胃癌]
[Methotrexate/5-fluorouracil therapy in gastric cancer with peritoneal metastasis].
作者信息
Kosaka T, Sugaya J, Sejima T, Takano Y, Nakano Y, Akiyama T, Kiriyama M, Tomita F, Saito H, Kita I
机构信息
2nd Dept. of Surgery, School of Medicine, Kanazawa Medical University.
出版信息
Gan To Kagaku Ryoho. 1994 Sep;21(13):2266-9.
PMID:7944456
Abstract
Eighteen patients with gastric cancer with peritoneal metastasis were treated with methotrexate/5-fluorouracil sequential therapy. In four patients, a partial response was obtained and in another four, symptomatic relief was obtained by the therapy. As side effects, BM suppression was seen in 9 and GI symptoms in 6 patients. Intraaortic, low-dose and 3-hour-interval procedure are recommended in the therapy.
摘要
18例伴有腹膜转移的胃癌患者接受了甲氨蝶呤/5-氟尿嘧啶序贯治疗。4例患者获得部分缓解，另外4例患者通过该治疗获得症状缓解。作为副作用，9例患者出现骨髓抑制，6例患者出现胃肠道症状。该治疗推荐采用主动脉内低剂量且间隔3小时的给药方案。
相似文献
1
[Methotrexate/5-fluorouracil therapy in gastric cancer with peritoneal metastasis].[甲氨蝶呤/5-氟尿嘧啶疗法用于治疗伴有腹膜转移的胃癌]
Gan To Kagaku Ryoho. 1994 Sep;21(13):2266-9.
2
[A case of type 4 gastric cancer with peritoneal dissemination treated with intra-aortic chemotherapy].[1例接受主动脉内化疗治疗的伴有腹膜播散的4型胃癌]
Gan To Kagaku Ryoho. 1999 Jun;26(7):975-8.
3
4
[Effective treatment of liver metastasis and peritoneal dissemination of gastric cancer using intra-arterial therapy--a case report].[动脉内介入治疗有效治疗胃癌肝转移及腹膜播散—— 1例报告]
Gan To Kagaku Ryoho. 1992 Aug;19(10 Suppl):1749-52.
5
[A study of arterial infusion chemotherapy for gastric cancer patients with peritoneal metastasis].[胃癌伴腹膜转移患者动脉灌注化疗的研究]
Gan To Kagaku Ryoho. 1996 Sep;23(11):1467-71.
6
[Experimental study on intraperitoneal sequential MTX/5-FU therapy for peritoneal seeding in comparison with intravenous administration].[腹腔内序贯应用甲氨蝶呤/5-氟尿嘧啶治疗腹膜种植转移的实验研究及与静脉给药的比较]
Gan To Kagaku Ryoho. 1997 Nov;24(14):2131-6.
7
Arterial infusion chemotherapy for peritoneal and liver metastasis in gastric cancer.动脉灌注化疗用于胃癌腹膜及肝转移
Gan To Kagaku Ryoho. 1997 May;24 Suppl 1:45-51.
8
9
Phase II study of sequential methotrexate and 5-fluorouracil chemotherapy against peritoneally disseminated gastric cancer with malignant ascites: a report from the Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group, JCOG 9603 Trial.甲氨蝶呤与5-氟尿嘧啶序贯化疗治疗伴有恶性腹水的腹膜播散性胃癌的II期研究：日本临床肿瘤学会胃肠肿瘤研究组JCOG 9603试验报告
Jpn J Clin Oncol. 2004 Jun;34(6):316-22. doi: 10.1093/jjco/hyh063.
10
[Sequential chemotherapy with methotrexate and 5-fluorouracil for advanced gastric cancer].[甲氨蝶呤与5-氟尿嘧啶序贯化疗用于晚期胃癌]
Gan To Kagaku Ryoho. 1998 Mar;25(4):541-6.
Zotero 插件