[甲氨蝶呤/5-氟尿嘧啶疗法用于治疗伴有腹膜转移的胃癌]
[Methotrexate/5-fluorouracil therapy in gastric cancer with peritoneal metastasis].
作者信息
Kosaka T, Sugaya J, Sejima T, Takano Y, Nakano Y, Akiyama T, Kiriyama M, Tomita F, Saito H, Kita I
机构信息
2nd Dept. of Surgery, School of Medicine, Kanazawa Medical University.
出版信息
Gan To Kagaku Ryoho. 1994 Sep;21(13):2266-9.
PMID:7944456
Abstract
Eighteen patients with gastric cancer with peritoneal metastasis were treated with methotrexate/5-fluorouracil sequential therapy. In four patients, a partial response was obtained and in another four, symptomatic relief was obtained by the therapy. As side effects, BM suppression was seen in 9 and GI symptoms in 6 patients. Intraaortic, low-dose and 3-hour-interval procedure are recommended in the therapy.
摘要
18例伴有腹膜转移的胃癌患者接受了甲氨蝶呤/5-氟尿嘧啶序贯治疗。4例患者获得部分缓解，另外4例患者通过该治疗获得症状缓解。作为副作用，9例患者出现骨髓抑制，6例患者出现胃肠道症状。该治疗推荐采用主动脉内低剂量且间隔3小时的给药方案。
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