Yokoyama S, Sugenoya A, Kasuga Y, Fujimori M, Oguchi M, Abe N, Tsuchiya S, Iida F
Dept. of Surgery, Shinshu University School of Medicine.
Gan To Kagaku Ryoho. 1994 Sep;21(13):2278-81.
Neoadjuvant therapy combined with intra-arterial continuous infusion of CDDP and external radiation was evaluated in a patient with locally advanced breast cancer. Although only MR was observed on the primary tumor, PR was found in several metastatic lymph nodes and daughter nodules. All tumor markers elevated before treatment decreased to normal ranges only by this therapy, and histological damage was also recognized remarkably with a high concentration of free Pt (8.89 micrograms/g) in cancer tissues. Since no severe side effects appeared during the present therapy, extended radical mastectomy with wide skin resection could be performed following additional intra-arterial chemotherapy using 5-FU, epi-ADM and MMC. From this experience, it was suggested that CDDP was an useful drug in the chemotherapy for breast cancer.
对一名局部晚期乳腺癌患者评估了新辅助治疗联合顺铂动脉内持续输注及外照射的效果。尽管在原发肿瘤上仅观察到微小反应，但在多个转移淋巴结和子结节中发现了部分缓解。治疗前升高的所有肿瘤标志物仅通过该治疗降至正常范围，并且在癌组织中高浓度的游离铂（8.89微克/克）下也明显观察到组织学损伤。由于在当前治疗期间未出现严重副作用，在使用5-氟尿嘧啶、表阿霉素和丝裂霉素进行额外的动脉内化疗后，可以进行广泛皮肤切除的扩大根治性乳房切除术。从这一经验来看，提示顺铂在乳腺癌化疗中是一种有用的药物。
