Hashimoto T, Saji S, Fukada D, Umemoto T, Kunieda K, Sugiyama Y, Asano M, Chikaishi T
Second Dept. of Surgery, Gifu University School of Medicine.
Gan To Kagaku Ryoho. 1994 Sep;21(13):2302-4.
The significance and effectiveness of adjuvant intraoperative chemotherapy using subserosal or submucosal administration of Neocarzinostatin (NCS) and CH 40 for gastric cancer and colorectal cancer were studied. Tissue NCS concentration of proximal lymph nodes were higher than for distant lymph nodes, while the immunocompetency of distant lymph nodes (lower NCS concentration) showed slightly higher activity than that of proximal lymph nodes. From these results, it is suggested that loco-regional administration of NCS might be effective for chemical lymph node cleaning of the cancer.
研究了采用丝裂霉素（NCS）和CH 40浆膜下或粘膜下给药进行胃癌和结直肠癌术中辅助化疗的意义和有效性。近端淋巴结的组织NCS浓度高于远端淋巴结，而远端淋巴结（NCS浓度较低）的免疫活性略高于近端淋巴结。从这些结果来看，提示NCS的局部区域给药可能对癌症的化学性淋巴结清扫有效。
