非心脏跳动尸体器官捐献。
Nonheartbeating cadaveric organ donation.
作者信息
Orloff M S, Reed A I, Erturk E, Kruk R A, Paprocki S A, Cimbalo S C, Cerilli G J
机构信息
Department of Surgery, University of Rochester Medical Center, New York 14642-8410.
出版信息
Ann Surg. 1994 Oct;220(4):578-83; discussion 583-5. doi: 10.1097/00000658-199410000-00016.
OBJECTIVE
The authors evaluated the potential use of nonheartbeating (NHB) cadaver donors as an additional source to the current supply of brain-dead cadaver donors.
SUMMARY BACKGROUND DATA
The numbers of cadaveric donors has not increased significantly during the last 5 years, despite a rising need for transplantable organs. Any improvement in cadaveric organ procurement will depend on the use of previously unrecognized potential donors.
METHODS
During a 2-year period, 24 kidneys were retrieved from 12 NHB donors. Nineteen kidneys were transplanted.
RESULTS
These kidneys sustained a mean warm ischemia time of 26 minutes (range 20-35 min). A mean lowest creatinine level of 2.0 mg/dL, (range 1.1-3.0 mg/dL), the rate of postoperative dialysis (22%), and a 1-year graft survival rate of 76% for kidneys from NHB-donated kidneys compare favorably to expected results achieved nationally from brain-dead cadaveric donors.
CONCLUSIONS
Nonheartbeating donor kidneys can yield acceptable graft function and be of no disadvantage to recipients of cadaver transplants.
目的
作者评估了非心跳（NHB）尸体供体作为当前脑死亡尸体供体来源补充的潜在用途。
总结背景数据
尽管对可移植器官的需求不断增加，但在过去5年中尸体供体数量并未显著增加。尸体器官获取的任何改善都将取决于对以前未被认识到的潜在供体的利用。
方法
在2年期间，从12名NHB供体获取了24个肾脏。其中19个肾脏进行了移植。
结果
这些肾脏的平均热缺血时间为26分钟（范围20 - 35分钟）。平均最低肌酐水平为2.0mg/dL（范围1.1 - 3.0mg/dL），术后透析率为22%，NHB供体肾脏的1年移植肾存活率为76%，与全国脑死亡尸体供体的预期结果相比具有优势。
结论
非心跳供体肾脏可产生可接受的移植肾功能，对尸体移植受者无不利影响。
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