Nahmias J, Goldsmith R, Soibelman M, el-On J
Department of Internal Medicine, Bylu Medical Center, Moztkin, Israel.
Ann Trop Med Parasitol. 1994 Jun;88(3):295-304. doi: 10.1080/00034983.1994.11812870.
Sixty-eight cystic echinococcosis patients were each treated with 800 mg albendazole/day in four 28-day courses separated by 14-day drug-free intervals. Follow-up for 3-7 years showed that this treatment alone eradicated the cysts in many patients; in most of the remainder, disease progression stopped. Of the 59 patients with liver cyst(s), 41% were cured (all cysts disappeared), 17% showed marked improvement (> 25% contraction, complete consolidation), 24% limited improvement and 15% no change. Of the 12 patients with lung cyst(s), 72% were cured, 9% showed limited improvement and 18% showed no change (18%). No patient worsened but a recurrence occurred in two patients at about 56 months. The times taken to detect an initial cyst change and to detect cure were longer than is generally expected; initial cyst changes and cure could only be detected after 1 year in 12% and 69% of patients with liver cysts and 22% and 37% of those with lung cysts, respectively.
68例囊性棘球蚴病患者，每日服用800毫克阿苯达唑，分四个疗程，每个疗程28天，疗程之间间隔14天无药期。3至7年的随访表明，仅这种治疗就使许多患者的囊肿得到根除；其余大多数患者的疾病进展停止。在59例肝囊肿患者中，41%治愈（所有囊肿消失），17%显著改善（收缩>25%，完全巩固），24%改善有限，15%无变化。在12例肺囊肿患者中，72%治愈，9%改善有限，18%无变化。无患者病情恶化，但有2例患者在约56个月时复发。检测到最初囊肿变化和治愈所需的时间比一般预期的要长；肝囊肿患者中分别有12%和69%、肺囊肿患者中分别有22%和37%在1年后才能检测到最初的囊肿变化和治愈。
