Nekrasova T P, Kondrat'eva O N
Arkh Patol. 1993 May-Jun;55(3):18-21.
28 liver biopsies from patients with sarcoidosis were studied with the use of multifactor mathematical methods. Granuloma morphogenesis in the liver results from the effect of the antigen (which is realized possibly through cytokines), "scarring" and "lymphoidization". Non-linear dependence between the morphogenesis factors is revealed and thus the hypothesis about the presence in the sarcoidosis liver of the three types of granulomas and their transformation from one type into another is confirmed.
利用多因素数学方法对28例结节病患者的肝脏活检组织进行了研究。肝脏中的肉芽肿形成是由抗原（可能通过细胞因子实现）、“瘢痕形成”和“淋巴样化”的作用导致的。揭示了形态发生因素之间的非线性依赖关系，从而证实了结节病肝脏中存在三种类型肉芽肿及其从一种类型转变为另一种类型的假说。
