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[血流动力学对人体主动脉粥样硬化病变空间组织的影响。脂肪条纹以及脂质纤维斑块和纤维斑块的局部差异]

[The hemodynamic effect on the spatial organization of atherosclerotic lesions in the human aorta. Topical differences in the fatty streaks and in the lipofibrous and fibrous plaques].

作者信息

Kolpakov V A, Solov'ev P B, Polishchuk R S, Bannykh S I, Mironov A A

出版信息

Arkh Patol. 1993 May-Jun;55(3):30-4.

PMID:7944966
Abstract

By means of light microscopy of whole-mounted membranous preparations and scanning electron microscopy differences of the three-dimensional organization in the fatty streaks, lipo-fibrous and fibrous plaques in proximal, distal and central parts were investigated. It was revealed that the central parts of the atherosclerotic lesions have a more mature character than the proximal and, especially, distal parts of the plaques. This phenomenon is accounted for by a progressive growth of the plaques along blood flow in distal direction due to the changes in hemodynamics.

摘要

通过对整个膜状制剂的光学显微镜检查和扫描电子显微镜检查,研究了近端、远端和中央部分脂肪条纹、脂纤维斑块和纤维斑块中三维组织结构的差异。结果显示,动脉粥样硬化病变的中央部分比斑块的近端,尤其是远端部分具有更成熟的特征。这种现象是由于血流动力学的变化,斑块沿血流方向向远端逐渐生长所致。

相似文献

1
[The hemodynamic effect on the spatial organization of atherosclerotic lesions in the human aorta. Topical differences in the fatty streaks and in the lipofibrous and fibrous plaques].[血流动力学对人体主动脉粥样硬化病变空间组织的影响。脂肪条纹以及脂质纤维斑块和纤维斑块的局部差异]
Arkh Patol. 1993 May-Jun;55(3):30-4.
2
[The hemodynamic effect on the spatial organization of atherosclerotic lesions in the human aorta. Plaques at the sites of arterial branching].
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[Changes in the 3-dimensional organization of the cellular system of the human aortic intima in atherosclerosis].
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Three-dimensional cytoarchitecture of normal and atherosclerotic intima of human aorta.
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Clonal characteristics of fibrous plaques and fatty streaks from human aortas.来自人类主动脉的纤维斑块和脂肪条纹的克隆特征。
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Smad expression in human atherosclerotic lesions: evidence for impaired TGF-beta/Smad signaling in smooth muscle cells of fibrofatty lesions.Smad蛋白在人类动脉粥样硬化病变中的表达:纤维脂肪病变平滑肌细胞中TGF-β/Smad信号传导受损的证据。
Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1391-6. doi: 10.1161/01.ATV.0000133605.89421.79. Epub 2004 May 27.
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Fibrous and lipid-rich atherosclerotic plaques are part of interchangeable morphologies related to inflammation: a concept.富含纤维和脂质的动脉粥样硬化斑块是与炎症相关的可互换形态的一部分:一种概念。
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C-reactive protein immunohistochemical localization in normal and atherosclerotic human aortas.C反应蛋白在正常和动脉粥样硬化人主动脉中的免疫组织化学定位
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[The use of freeze fracturing in combination with light, scanning and transmission electron microscopy for studying the structure of the normal and atherosclerotically altered human aortic intima].[冷冻断裂联合光镜、扫描电镜及透射电镜用于研究正常及动脉粥样硬化改变的人主动脉内膜结构]
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Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability.在人类主动脉粥样硬化斑块破裂病变中,斑块新生血管形成增加:对斑块易损性的影响。
Circulation. 2004 Oct 5;110(14):2032-8. doi: 10.1161/01.CIR.0000143233.87854.23. Epub 2004 Sep 27.

引用本文的文献

1
Opinion: On the Way towards the New Paradigm of Atherosclerosis.观点:走向动脉粥样硬化新模式之路。
Int J Mol Sci. 2022 Feb 15;23(4):2152. doi: 10.3390/ijms23042152.