[The hemodynamic effect on the spatial organization of atherosclerotic lesions in the human aorta. Topical differences in the fatty streaks and in the lipofibrous and fibrous plaques].

By means of light microscopy of whole-mounted membranous preparations and scanning electron microscopy differences of the three-dimensional organization in the fatty streaks, lipo-fibrous and fibrous plaques in proximal, distal and central parts were investigated. It was revealed that the central parts of the atherosclerotic lesions have a more mature character than the proximal and, especially, distal parts of the plaques. This phenomenon is accounted for by a progressive growth of the plaques along blood flow in distal direction due to the changes in hemodynamics.