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棕色脂肪组织中的CCAAT/增强子结合蛋白α和β：发育过程中组织特异性表达模式的证据

CCAAT/enhancer-binding proteins alpha and beta in brown adipose tissue: evidence for a tissue-specific pattern of expression during development.

作者信息

Manchado C, Yubero P, Viñas O, Iglesias R, Villarroya F, Mampel T, Giralt M

机构信息

Departament de Bioquímica i Fisiologia, Universitat de Barcelona, Spain.

出版信息

Biochem J. 1994 Sep 15;302 ( Pt 3)(Pt 3):695-700. doi: 10.1042/bj3020695.

DOI:10.1042/bj3020695
PMID:7945193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1137287/
Abstract

CCAAT/enhancer-binding protein (C/EBP) alpha mRNA and its protein products C/EBP alpha and 30 kDa C/EBP alpha are expressed in rat brown-adipose tissue. Results also demonstrate the expression of C/EBP beta mRNA and its protein products C/EBP beta and liver inhibitory protein (LIP) in the tissue. The abundance of C/EBP alpha and C/EBP beta proteins in adult brown fat is similar to that found in adult liver. However, the expression of C/EBP alpha and C/EBP beta is specifically regulated in brown fat during development. C/EBP alpha, 30 kDa C/EBP alpha, C/EBP beta and LIP content is several-fold higher in fetal brown fat than in the adult tissue, or liver at any stage of development. Peak values are attained in late fetal life, in concurrence with the onset of transcription of the uncoupling protein (UCP) gene, the molecular marker of terminal brown-adipocyte differentiation. When adult rats are exposed to a cold environment, which is a physiological stimulus of brown-adipose tissue hyperplasia and UCP gene expression, a specific rise in C/EBP beta expression with respect to C/EBP alpha, 30 kDa C/EBP alpha and LIP is observed. Present data suggest that the C/EBP family of transcription factors has an important role in the development and terminal differentiation of brown-adipose tissue.

摘要

CCAAT/增强子结合蛋白（C/EBP）α信使核糖核酸及其蛋白产物C/EBPα和30 kDa C/EBPα在大鼠棕色脂肪组织中表达。结果还证明了C/EBPβ信使核糖核酸及其蛋白产物C/EBPβ和肝脏抑制蛋白（LIP）在该组织中的表达。成年棕色脂肪中C/EBPα和C/EBPβ蛋白的丰度与成年肝脏中的相似。然而，在发育过程中，棕色脂肪中C/EBPα和C/EBPβ的表达受到特异性调节。胎儿棕色脂肪中C/EBPα、30 kDa C/EBPα、C/EBPβ和LIP的含量比成年组织或任何发育阶段的肝脏中的含量高几倍。在胎儿后期达到峰值，与解偶联蛋白（UCP）基因转录的开始同时出现，UCP基因是终末棕色脂肪细胞分化的分子标志物。当成年大鼠暴露于寒冷环境中时，寒冷环境是棕色脂肪组织增生和UCP基因表达的生理刺激因素，观察到C/EBPβ相对于C/EBPα、30 kDa C/EBPα和LIP的表达有特异性升高。目前的数据表明，转录因子C/EBP家族在棕色脂肪组织的发育和终末分化中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f43/1137287/670d7604e917/biochemj00079-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f43/1137287/670d7604e917/biochemj00079-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f43/1137287/670d7604e917/biochemj00079-0081-a.jpg

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