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Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP.

作者信息

Takeda K, Oida S, Ichijo H, Iimura T, Maruoka Y, Amagasa T, Sasaki S

机构信息

Department of Biochemistry, Tokyo Medical and Dental University, Japan.

出版信息

Biochem Biophys Res Commun. 1994 Oct 14;204(1):203-9. doi: 10.1006/bbrc.1994.2445.

DOI:10.1006/bbrc.1994.2445
PMID:7945360
Abstract

A cDNA for the rat bone morphogenetic protein (BMP) type IA receptor (BMPR-IA) was isolated from a dental pulp cell cDNA library. The rat BMPR-IA cDNA encodes a protein of 532 amino acids with a single transmembrane domain and a putative serine/threonine kinase domain. The overall amino acid sequence identity between the rat and human BMPR-IA was 97%. Reverse transcriptase-polymerase chain reaction analysis revealed that BMPR-IA mRNA was highly expressed in the BMP-induced bone forming tissues throughout the stages tested.

摘要

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