Synthesis and pharmacological evaluation of some 3-phenacyl-5-benzylidene-thiazolidine-2,4-diones.
作者信息
de Lima J G, Perrissin M, Chantegrel J, Luu-Duc C, Rousseau A, Narcisse G
机构信息
Laboratoire de Chimie-Pharmacie, Unité de Recherche Associée au Centre National de la Recherche Scientifique 1287, Faculté de Pharmacie de Grenoble, La Tronche, France.
出版信息
Arzneimittelforschung. 1994 Jul;44(7):831-4.
PMID:7945517
Abstract
The synthesis of 54 3-phenacyl-5-benzylidene-thiazolidine-2,4-diones is reported. Eight of them were tested for anti-oedema, analgesic and anticonvulsant activity. Only one compound showed significant anti-oedematous and analgesic activity. Three compounds protected against tonic seizures and death.
摘要
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