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急性脑损伤中的脑脊液酶。2. 脑脊液酶活性与脑损伤程度的关系。

Cerebrospinal fluid enzymes in acute brain injury. 2. Relation of CSF enzyme activity to extent of brain injury.

作者信息

Maas A I

出版信息

J Neurol Neurosurg Psychiatry. 1977 Jul;40(7):666-74. doi: 10.1136/jnnp.40.7.666.

Abstract

The value of CSF enzyme estimations as indices of the extent of brain damage was studied in the experimental situation. Standard cold lesions of different severity were induced in cats. The activities of the enzymes CPK, HBDH, LDH, GOT, AND ChE were studied at half hour intervals in the cerebrospinal fluid (CSF). The ventricular and cisternal fluid pressure, and the arterial blood pressure were monitored continuously. Significantly higher enzyme levels were found in the animals with more severe injuries of the brain.

摘要

在实验情况下,研究了脑脊液酶测定作为脑损伤程度指标的价值。在猫身上诱导出不同严重程度的标准冷损伤。每隔半小时研究脑脊液(CSF)中肌酸磷酸激酶(CPK)、α-羟丁酸脱氢酶(HBDH)、乳酸脱氢酶(LDH)、谷草转氨酶(GOT)和胆碱酯酶(ChE)的活性。持续监测脑室和脑池内的液体压力以及动脉血压。在脑损伤更严重的动物中发现酶水平显著更高。

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本文引用的文献

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Cerebrospinal fluid and serum transaminases and lactic dehydrogenase after head injury.
Acta Neurol Scand. 1968;44(1):124-9. doi: 10.1111/j.1600-0404.1968.tb07449.x.
6
Enzyme analysis for evaluating acute head injury.
Acta Chir Scand. 1971;137(4):305-9.
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Spinal fluid and blood serum enzyme activity in brain injuries.
J Neurosurg. 1974 Aug;41(2):224-8. doi: 10.3171/jns.1974.41.2.0224.
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Prognosis after severe head injury.重度颅脑损伤后的预后。
Clin Neurosurg. 1972;19:200-7. doi: 10.1093/neurosurgery/19.cn_suppl_1.200.

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