Glantz J C, Abramowicz J S, Sherer D M
Department of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry, New York.
Am J Perinatol. 1994 Jul;11(4):305-8. doi: 10.1055/s-2007-994599.
It is uncertain whether idiopathic midtrimester polyhydramnios is associated with adverse perinatal outcome. Fifty patients with midtrimester polyhydramnios without apparent etiology were compared to 85 control patients. Demographic, obstetric, and neonatal data were recorded and compared using chi-square, Fisher's exact, and Student t tests. Comparisons were also made within the study group between those patients with resolution of the polyhydramnios and those with persistence. Demographic and obstetric data were similar in both groups. Of study patients, 94% had mild polyhydramnios, which resolved in 75.6% of those having follow-up scans. There were no differences in neonatal outcome between study and control groups. Fetal aneuploidy was increased in the persistent polyhydramnios group (2 of 10, 20%) compared to the group with spontaneous resolution (none of 33, 0%), P = 0.049. Mild idiopathic midtrimester polyhydramnios resolves frequently and, if so, is not associated with adverse perinatal outcome. However, persistence of polyhydramnios is associated with an increased risk of fetal aneuploidy, and fetal karyotyping should be considered.
特发性孕中期羊水过多是否与不良围产期结局相关尚不确定。将50例无明显病因的孕中期羊水过多患者与85例对照患者进行比较。记录人口统计学、产科和新生儿数据，并使用卡方检验、费舍尔精确检验和学生t检验进行比较。还在研究组内对羊水过多得到缓解的患者和持续存在羊水过多的患者进行了比较。两组的人口统计学和产科数据相似。在研究患者中，94%为轻度羊水过多，其中75.6%在进行随访扫描的患者中得到缓解。研究组和对照组的新生儿结局无差异。与自发缓解组（33例中无1例，0%）相比，持续性羊水过多组（10例中有2例，20%）的胎儿非整倍体增加，P = 0.049。轻度特发性孕中期羊水过多常可缓解，若如此，则与不良围产期结局无关。然而，羊水过多持续存在与胎儿非整倍体风险增加相关，应考虑进行胎儿核型分析。
