Cytotoxic activity of two new lipophilic steroid nitrogen carbamates incorporated into low-density lipoprotein.

Low-density lipoprotein (LDL) is a potential drug carrier in cancer chemotherapy. Two novel cytotoxic lipophilic steroid derivatives with two nitrogen carbamate groups on a C-17 side chain were successfully incorporated into LDL using a reassembly technique. The antineoplastic activity of the new agents against T-47D breast cancer cells in culture was approximately twice that of a previously characterized compound with only one such group.