Wayner M J, Polan-Curtain J L, Chiu S C, Armstrong D L
Division of Life Sciences, University of Texas at San Antonio 78249-0662.
Alcohol. 1994 Jul-Aug;11(4):343-6. doi: 10.1016/0741-8329(94)90102-3.
Results of a previous study showed that ethanol inhibition of hippocampal long-term potentiation (LTP) induction was mediated by angiotensin II (AII) and the AT1 subtype receptor because it was blocked by losartan, a specific AT1 antagonist. Because LTP is an important hippocampal function involved in the memory process and other behaviors, it is possible that losartan might block some of the directly observable ethanol-induced changes in rat behavior. Results demonstrate that losartan can effectively block some of the intoxicating effects of low doses of ethanol, 2 g/kg PO or IP. However, even a high dose of losartan 20 mg/kg IP, did not reduce significantly any of the intoxicating effects of the higher dose of 4 g/kg administered by gavage. Higher doses of ethanol might be more difficult to block because of a direct effect on the post synaptic membrane.
先前一项研究的结果表明，乙醇对海马体长期增强（LTP）诱导的抑制作用是由血管紧张素II（AII）和AT1亚型受体介导的，因为它可被特异性AT1拮抗剂氯沙坦阻断。由于LTP是参与记忆过程和其他行为的一项重要海马体功能，氯沙坦有可能会阻断一些在大鼠行为中可直接观察到的乙醇诱导变化。结果表明，氯沙坦能够有效阻断低剂量乙醇（2 g/kg口服或腹腔注射）的一些中毒效应。然而，即使腹腔注射20 mg/kg的高剂量氯沙坦，也未显著降低经灌胃给予的4 g/kg高剂量乙醇的任何中毒效应。由于对突触后膜有直接作用，更高剂量的乙醇可能更难被阻断。
