Lees P D, Fahlbusch R, Zrinzo A, Pickard J D
Clinical Neurological Sciences Group, University of Southampton, Wessex Neurological Centre, Southampton General Hospital, UK.
Br J Neurosurg. 1994;8(3):313-8. doi: 10.3109/02688699409029619.
In a two-centre study, intrasellar pituitary tissue pressure was measured at transsphenoidal surgery in 107 patients with pituitary adenomas or intrasellar cysts. 'Normal' ISP in patients under anaesthesia with small microadenomas (< 5 mm diameter) or a partial empty sella was 12 +/- 3 mmHg. Raised ISP (> 15 mmHg) was found in 75% of cases. The highest pressures were recorded in tumours with parasellar invasion (30 +/- 2; p < 0.01) irrespective of size and extension in other directions. In non-invasive lesions there was no correlation between the level of raised ISP and tumour size. Hypopituitarism and stalk compression syndrome were both associated with higher ISP than patients with normal pituitary function.
在一项双中心研究中，对107例垂体腺瘤或鞍内囊肿患者在经蝶窦手术时测量了鞍内垂体组织压力。麻醉状态下微小腺瘤（直径<5mm）或部分空蝶鞍患者的“正常”鞍内压力为12±3mmHg。75%的病例发现鞍内压力升高（>15mmHg）。无论肿瘤大小及向其他方向的扩展情况如何，蝶鞍旁侵犯的肿瘤记录到的压力最高（30±2；p<0.01）。在非侵袭性病变中，鞍内压力升高水平与肿瘤大小之间无相关性。与垂体功能正常的患者相比，垂体功能减退和垂体柄受压综合征患者的鞍内压力均更高。
