Tomten S E, Kjeldsen S E, Nilsson S, Westheim A S
Norwegian Institute for Sports Medicine Ltd., Oslo.
Am J Hypertens. 1994 Jul;7(7 Pt 1):603-8. doi: 10.1093/ajh/7.7.603.
The effect of alpha 1-adrenoceptor blockade (doxazosin, 4 mg daily) on maximal VO2 and physical endurance capacity in 16 mildly hypertensive, athletic men was investigated in a randomized, placebo-controlled, double-blind, two-period of 4 weeks, cross-over study. The maximal workload obtained during graded bicycle ergometer exercise and the corresponding maximal VO2 were reduced by 16 +/- 3 W (mean +/- SE), (P = .00003) and 3 +/- 1 mL/(kg.min) (P = .0004), respectively, on doxazosin compared with placebo. The running time on a 5000 m track increased by 43 +/- 12 sec on doxazosin (P = .04). Heart rate was unchanged during the running session. Systolic blood pressure was reduced by 9 +/- 4.1 mm Hg (P = .04) immediately after finishing 5000 m. Six subjects reported side effects from doxazosin (headache, fatigue, and leg pain). Thus, antihypertensive treatment with alpha 1-selective adrenoceptor blockade moderately, but significantly, reduces maximal O2 consumption and high intensity physical endurance capacity in mildly hypertensive athletic men. Significantly reduced systolic blood pressure and unchanged heart rate immediately after running, combined with unchanged heart rate during the race may, however, suggest a safer exercise performance.
在一项随机、安慰剂对照、双盲、为期4周的两阶段交叉研究中，研究了α1肾上腺素能受体阻滞剂（多沙唑嗪，每日4毫克）对16名轻度高血压、爱运动男性的最大摄氧量和身体耐力的影响。与安慰剂相比，多沙唑嗪治疗组在分级自行车测力计运动中获得的最大工作量及相应的最大摄氧量分别降低了16±3瓦（平均值±标准误），（P = 0.00003）和3±1毫升/（千克·分钟）（P = 0.0004）。在5000米跑道上的跑步时间，多沙唑嗪治疗组增加了43±12秒（P = 0.04）。跑步过程中心率未发生变化。跑完5000米后，收缩压立即降低了9±4.1毫米汞柱（P = 0.04）。6名受试者报告了多沙唑嗪的副作用（头痛、疲劳和腿痛）。因此，α1选择性肾上腺素能受体阻滞剂进行的抗高血压治疗适度但显著地降低了轻度高血压爱运动男性的最大耗氧量和高强度身体耐力。然而，跑步后收缩压显著降低且心率未变，同时跑步过程中心率也未变，这可能表明运动表现更安全。
