Lawler D A
Crit Care Nurs Clin North Am. 1994 Jun;6(2):265-74.
This article describes some of the alterations that occur in the neuroendocrine system during sepsis. With a goal of better management of the patient with sepsis, an overview of the endocrine system, its hormones, and its close relationship to the nervous system is presented. The importance of hormone target cell receptor coupling, specific mechanisms of action that result in physiological changes, and regulation of hormone secretion are detailed. The roles and effects of catecholamines, glucagon, cortisol, and growth hormone are explored. Sick euthyroid syndrome, alterations in ADH, the renin-angiotensin-aldosterone axis, and PTH secretion are also examined.
本文描述了脓毒症期间神经内分泌系统发生的一些改变。为了更好地管理脓毒症患者，本文对内分泌系统、其激素以及它与神经系统的密切关系进行了概述。详细介绍了激素靶细胞受体偶联的重要性、导致生理变化的具体作用机制以及激素分泌的调节。探讨了儿茶酚胺、胰高血糖素、皮质醇和生长激素的作用及影响。还研究了低T3综合征、抗利尿激素的改变、肾素 - 血管紧张素 - 醛固酮轴以及甲状旁腺激素分泌的变化。
