Fern R, Harrison P J
Department of Physiology, University College London.
Exp Physiol. 1994 Jul;79(4):571-81. doi: 10.1113/expphysiol.1994.sp003790.
Unitary action potentials have been recorded from cat spinal root filaments following electrical stimulation of hindlimb peripheral nerves. Potentials were monitored both before the ischaemia which follows the onset of cardiac arrest. The relationship between time to conduction failure (survival time) and initial conduction velocity was determined for 164 nerve fibres. This revealed that during ischaemia, slow myelinated axons tend to fail before fast myelinated axons. The average survival time was 24.6 min (range 11-39 min). The results are discussed in terms of (i) the possible mechanisms underlying ischaemic conduction block, (ii) their clinical implications for the role of ischaemia in peripheral neuropathies, and (iii) using ischaemia as an experimental technique to produce a differential nerve block.
在对猫后肢周围神经进行电刺激后，从猫的脊髓神经根细丝记录到了单一动作电位。在心脏骤停开始后的缺血发生之前，对电位进行了监测。确定了164条神经纤维的传导失败时间（存活时间）与初始传导速度之间的关系。这表明在缺血期间，慢髓鞘轴突往往比快髓鞘轴突更早发生传导失败。平均存活时间为24.6分钟（范围为11 - 39分钟）。从以下几个方面对结果进行了讨论：（i）缺血性传导阻滞的潜在机制；（ii）它们对缺血在周围神经病变中作用的临床意义；（iii）将缺血用作产生差异性神经阻滞的实验技术。
