Fern R, Harrison P J
Department of Physiology, University College London.
Exp Physiol. 1994 Jul;79(4):583-92. doi: 10.1113/expphysiol.1994.sp003791.
The pattern of conduction block induced in cat peripheral nerve by compression has been investigated electrophysiologically by recording unitary action potentials. A degree of compression, associated with chronic compression disorders in man, was applied to the cat sciatic nerve and resulted in a conduction block typified by early failure of the slow conducting myelinated axons. By contrast, a greater degree of compression, a degree more likely to result in acute compression lesions, produced a different pattern of effect, inducing early conduction failure in the fast conducting myelinated axons. These results are related to earlier studies which have shown that nerve deformation during compression has a differential action upon fast myelinated axons, while nerve ischaemia has a differential action upon slow myelinated axons.
通过记录单纤维动作电位，对猫外周神经受压诱发的传导阻滞模式进行了电生理学研究。将与人的慢性压迫性疾病相关的一定程度压迫施加于猫的坐骨神经，导致传导阻滞，其典型表现为慢传导有髓轴突早期功能障碍。相比之下，更大程度的压迫，即更有可能导致急性压迫性损伤的程度，产生了不同的效应模式，在快传导有髓轴突中诱发早期传导功能障碍。这些结果与早期研究相关，早期研究表明，压迫过程中的神经变形对快有髓轴突有不同作用，而神经缺血对慢有髓轴突有不同作用。
