Tsuchiya K, Watabiki S, Owada K, Kusano F, Hamaguchi H, Horikawa N, Li E, Sano M
Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan.
No To Shinkei. 1994 Aug;46(8):787-92.
We report two patients with Pick's disease in senescence. Patient 1 is a 78-year-old woman. She developed abnormal behavior at the age of 76 years. Neurological examination at age 76 revealed poor rapport, easy angriness, "Denkfaulheit", oral tendency, and slight dementia [WAIS (Wechsler Adult intelligence Scale) total IQ 62]. Cranial CT scan and MRI showed bilateral atrophy of the frontal and temporal lobe, especially of the temporal lobe. Patient 2 is a 73-year-old man. He developped sexual abnormal behavior and "triebhafte Hemmungslossigkeit" at the age of 71 years. Neurological examination at age 72 revealed poor rapport, lack of spontaneity, easy angriness, "Denkfaulheit", and slight dementia [WAIS total IQ 91]. Transient "stehende Redensarten" was noticed. Cranial CT scan and MRI showed bilateral atrophy of the frontal and temporal lobe, especially of the frontal lobe. To our knowledge, Pick's disease with an onset in the senescence is very rare. Pick's disease should be included in the differential diagnosis of abnormal behavior in the senescence.
我们报告了两例老年期皮克病患者。病例1是一名78岁女性。她在76岁时出现行为异常。76岁时的神经学检查发现关系不协调、易激惹、“思维迟缓”、口欲倾向及轻度痴呆[韦氏成人智力量表（WAIS）总智商62]。头颅CT扫描和磁共振成像（MRI）显示双侧额叶和颞叶萎缩，尤其是颞叶。病例2是一名73岁男性。他在71岁时出现性异常行为及“冲动抑制缺乏”。72岁时的神经学检查发现关系不协调、缺乏主动性、易激惹、“思维迟缓”及轻度痴呆[WAIS总智商91]。注意到有短暂的“固定套语”。头颅CT扫描和MRI显示双侧额叶和颞叶萎缩，尤其是额叶。据我们所知，老年期起病的皮克病非常罕见。皮克病应纳入老年期异常行为的鉴别诊断。
