Tapia M, Richard C, Baro J, Salesa R, Figols J, Zurbano F, Zubizarreta A
Department of Haematology, Marqués de Valdecilla University Hospital, University of Cantabria, Spain.
Br J Haematol. 1994 May;87(1):212-4. doi: 10.1111/j.1365-2141.1994.tb04897.x.
We report four cases of Scedosporium inflatum (S. inflatum) infection in severely immunocompromised haematological patients. Six well-documented cases of S. inflatum disseminated infection in haematological patients have been reported: four in Australia and two in Spain. Their clinical and pathological characteristics are heterogenous, particularly in the Australian cases. However, the clinical and pathological profile emerging from our and other Spanish cases is homogenous and very similar to the clinico-pathological spectrum of other disseminated mycoses, including Aspergillus and S. apiospermum. The optimal treatment of S. inflatum infection is unknown and the outcome in haematological patients is very poor. Eight patients died despite systemic antifungal treatment.
我们报告了4例严重免疫功能低下血液病患者发生的膨胀赛多孢菌（S. inflatum）感染。已有6例血液病患者发生S. inflatum播散性感染的详细记录报道：4例在澳大利亚，2例在西班牙。其临床和病理特征具有异质性，尤其是在澳大利亚的病例中。然而，我们的病例及其他西班牙病例所呈现的临床和病理特征是一致的，且与包括曲霉菌和阿利什霉在内的其他播散性真菌病的临床病理谱非常相似。膨胀赛多孢菌感染的最佳治疗方法尚不清楚，血液病患者的预后非常差。尽管进行了全身抗真菌治疗，仍有8例患者死亡。
