Bilgrami S, Almeida G D, Quinn J J, Tuck D, Bergstrom S, Dainiak N, Poliquin C, Ascensao J L
Department of Medicine, University of Nevada, Reno.
Br J Haematol. 1994 Jun;87(2):357-62. doi: 10.1111/j.1365-2141.1994.tb04922.x.
We describe the clinical course of three cytomegalovirus-antibody-positive allogeneic marrow graft recipients who developed progressive pancytopenia during the third month post-transplant. Bone marrow biopsy cores were hypocellular without evidence of disease recurrence. Haemopoietic progenitor assays demonstrated a decrease of all assayable progenitors. Cytomegalovirus was identified from the blood and urine of all three patients. However, none of the patients developed other manifestations of cytomegalovirus infection such as pneumonitis, hepatitis and enteritis. The therapeutic use of ganciclovir and intravenous immunoglobulins resulted in prompt resolution of both viraemia and viruria in all three patients, and of pancytopenia in two patients.
我们描述了三名巨细胞病毒抗体阳性的异基因骨髓移植受者的临床病程，他们在移植后第三个月出现了进行性全血细胞减少。骨髓活检核心部位细胞减少，无疾病复发迹象。造血祖细胞检测显示所有可检测的祖细胞均减少。在所有三名患者的血液和尿液中均检测到巨细胞病毒。然而，所有患者均未出现巨细胞病毒感染的其他表现，如肺炎、肝炎和肠炎。使用更昔洛韦和静脉注射免疫球蛋白进行治疗后，所有三名患者的病毒血症和病毒尿均迅速消退，两名患者的全血细胞减少也得到缓解。
