阵发性睡眠性血红蛋白尿后的骨髓发育异常：一个独立克隆出现的证据。
Myelodysplasia following paroxysmal nocturnal haemoglobinuria: evidence for the emergence of a separate clone.
作者信息
van Kamp H, Smit J W, van den Berg E, Ruud Halie M, Vellenga E
机构信息
Department of Haematology, University of Groningen, The Netherlands.
出版信息
Br J Haematol. 1994 Jun;87(2):399-400. doi: 10.1111/j.1365-2141.1994.tb04929.x.
Abstract
A patient with paroxysmal nocturnal haemoglobinuria (PNH) who developed a myelodysplastic syndrome (MDS) is described. After the onset of myelodysplasia the neutrophils of the patient fully expressed GPI-linked proteins. It is concluded that the myelodysplasia does not originate from transformed PNH stem cells, but represents the emergence of a separate clone arising from an injured marrow.
摘要
本文描述了一名阵发性睡眠性血红蛋白尿（PNH）患者发展为骨髓增生异常综合征（MDS）的病例。骨髓发育异常发生后，该患者的中性粒细胞充分表达糖基磷脂酰肌醇（GPI）连接蛋白。结论是，骨髓发育异常并非起源于转化的PNH干细胞，而是代表了受损骨髓中一个独立克隆的出现。
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