伴有t(2;5)(p23;q35)易位的嗜酸性粒细胞白血病。
Eosinophilic leukaemia with a t(2;5) (p23;q35) translocation.
作者信息
Sato H, Danbara M, Tamura M, Morita M
机构信息
Fourth Department of Internal Medicine, Teikyo University School of Medicine, Kanagawa, Japan.
出版信息
Br J Haematol. 1994 Jun;87(2):404-6. doi: 10.1111/j.1365-2141.1994.tb04931.x.
Although the diagnosis of rare eosinophilic leukaemia is possible based on cytogenetic abnormalities, the chromosomal aberrations reported are diverse. We found a t(2;5) (p23;q35) translocation on bone marrow cells of a patient with chronic eosinophilia who suffered from multiple pustular folliculitis but lacked the clinical symptoms commonly observed in hypereosinophilic syndrome. No morphological abnormalities in an eosinophilic series were apparent and other haemopoietic cells were well preserved. A therapeutic trial with interferon-alpha failed after a 2-month period, and the patient is currently undergoing a combination therapy with interferon and intermittent administrations of hydroxyurea.
尽管基于细胞遗传学异常有可能诊断出罕见的嗜酸性粒细胞白血病，但所报道的染色体畸变多种多样。我们在一名患有慢性嗜酸性粒细胞增多症且患有多发性脓疱性毛囊炎但缺乏高嗜酸性粒细胞综合征常见临床症状的患者的骨髓细胞中发现了t(2;5)(p23;q35)易位。嗜酸性粒细胞系列未见形态学异常，其他造血细胞保存良好。α干扰素治疗试验在2个月后失败，该患者目前正在接受干扰素与间歇性服用羟基脲的联合治疗。
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