Nakai H, Misawa S, Taniwaki M, Horiike S, Takashima T, Seriu T, Nakagawa H, Fujii H, Shimazaki C, Maruo N
Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Br J Haematol. 1994 Jun;87(2):425-7. doi: 10.1111/j.1365-2141.1994.tb04938.x.
In 31 cases of chronic myelogenous leukaemia (CML) we examined the prognostic significance of chromosomal loss of a 17p and p53 mutations at the onset of blast crisis (BC). p53 mutations were closely related to a shortened survival in CML-BC (P < 0.005 by the logrank test), whereas loss of a 17p by itself was not a poor prognostic indicator. The prognostic significance of loss of a 17p, however, emerged when combined with its predominance in the metaphases analysed. This predominance might easily and rapidly be screened by polymerase chain reaction-based analysis in about half of the cases.
在31例慢性粒细胞白血病（CML）患者中，我们研究了急变期（BC）开始时17号染色体短臂缺失及p53突变的预后意义。p53突变与CML-BC患者生存期缩短密切相关（对数秩检验P<0.005），而单纯17号染色体短臂缺失并非不良预后指标。然而，当17号染色体短臂缺失与分析中期相中其优势存在相结合时，其预后意义显现出来。在约半数病例中，基于聚合酶链反应的分析可轻松快速筛查出这种优势存在。
