基于新型大分子二醇和二苯基甲烷二异氰酸酯的聚氨酯的体内评估

In vivo evaluation of polyurethanes based on novel macrodiols and MDI.

作者信息

Brandwood A, Meijs G F, Gunatillake P A, Noble K R, Schindhelm K, Rizzardo E

机构信息

Centre for Biomedical Engineering, University of New South Wales, Kensington, Australia.

出版信息

J Biomater Sci Polym Ed. 1994;6(1):41-54. doi: 10.1163/156856295x00742.

DOI:10.1163/156856295x00742

PMID:7947472

Abstract

A series of novel polyurethane elastomers based on methylenediphenyl diisocyanate, 1,4-butanediol and the macrodiols, poly(hexamethylene oxide), poly(octamethylene oxide), and poly(decamethylene oxide) were implanted subcutaneously in sheep for periods of 3 and 6 months. The specimens that were subjected to 3 months of implantation were strained to 250% of their resting length, while those implanted for 6 months had no applied external strain. SEM examination of the explanted specimens revealed that the novel materials displayed resistance to environmental stress cracking. Proprietary materials, Pellethane 2363-80A, Biomer and Tecoflex EG-80A, which had been implanted under identical conditions, showed evidence of significant stress cracking. The extent of stress cracking in the 3-month strained experiment was similar to that from the 6-month unstrained experiment. Stress cracking was also observed in Pellethane 2363-55D, when implanted for 6 months (unstrained). Neither changes in molecular weight nor in tensile properties provided a clear indication of early susceptibility to degradation by environmental stress cracking.

摘要

一系列基于亚甲基二苯基二异氰酸酯、1,4 - 丁二醇和大分子二醇（聚（氧化六亚甲基）、聚（氧化八亚甲基）和聚（氧化十亚甲基））的新型聚氨酯弹性体被皮下植入绵羊体内3个月和6个月。植入3个月的标本被拉伸至其静止长度的250%，而植入6个月的标本未施加外部应变。对取出的标本进行扫描电子显微镜（SEM）检查发现，这些新型材料表现出抗环境应力开裂的性能。在相同条件下植入的专利材料佩尔thane 2363 - 80A、生物材料和泰科弗莱克斯EG - 80A，显示出明显的应力开裂迹象。3个月拉伸实验中的应力开裂程度与6个月未拉伸实验中的相似。当佩尔thane 2363 - 55D植入6个月（未拉伸）时，也观察到了应力开裂。分子量和拉伸性能的变化均未明确表明对环境应力开裂降解的早期敏感性。