Pearce J M, Hamid R I
Department of Obstetrics and Gynaecology, St George's Hospital, London.
Br J Obstet Gynaecol. 1994 Aug;101(8):685-8. doi: 10.1111/j.1471-0528.1994.tb13185.x.
To determine whether the use of human chorionic gonadotrophin (hCG) would reduce the recurrent miscarriage rate in women with polycystic ovarian disease.
Double-blind, prospective, randomised controlled trial.
A pregnancy loss clinic in a London teaching hospital.
One hundred and ninety-one women with a history of three consecutive spontaneous first trimester miscarriages and polycystic ovary syndrome.
10,000 i.u. of hCG or a placebo were given when the leading follicle was > or = 21 mm, then 5000 i.u. of hCG or a placebo were given twice weekly until miscarriage or the tenth week of pregnancy.
Miscarriage rate.
Women with polycystic ovaries who received hCG treatment had a lower miscarriage rate (14%) compared with women who received placebo (43%). In women with follicular phase luteinising hormone > 10 iu/l, those who received hCG therapy had a miscarriage rate of 10% compared with a rate of 44% in women who received the placebo. When clomiphene was used for ovulation induction, women treated with hCG had a miscarriage rate of 14% compared with a rate 47% in women who received the placebo. There was no significant benefit from hCG therapy in natural cycles.
The use of hCG in women with recurrent miscarriage and polycystic ovary syndrome improves the pregnancy outcome.
确定使用人绒毛膜促性腺激素（hCG）是否会降低多囊卵巢疾病女性的复发性流产率。
双盲、前瞻性、随机对照试验。
伦敦一家教学医院的流产诊所。
191名有连续三次孕早期自然流产史且患有多囊卵巢综合征的女性。
当主导卵泡≥21毫米时，给予10000国际单位的hCG或安慰剂，然后每周两次给予5000国际单位的hCG或安慰剂，直至流产或怀孕第10周。
流产率。
接受hCG治疗的多囊卵巢女性流产率（14%）低于接受安慰剂的女性（43%）。在卵泡期促黄体生成素>10国际单位/升的女性中，接受hCG治疗的女性流产率为10%，而接受安慰剂的女性流产率为44%。当使用克罗米芬诱导排卵时，接受hCG治疗的女性流产率为14%，而接受安慰剂的女性流产率为47%。在自然周期中，hCG治疗没有显著益处。
在复发性流产且患有多囊卵巢综合征的女性中使用hCG可改善妊娠结局。
