Vague P, Ramahandridona G, Vialettes B
Nouv Presse Med. 1976 Dec 25;5(4):3001-4.
Various parameters of the insulin secretion in man may be appreciated and calculated by studying the insulin response to an intravenous pulse of glucose followed 120 minutes later by one of tolbutamide. The relative insensitivity of the B cell to glucose, probable marker of a constitutional pancreatic predisposition to diabetes may be assessed in a given individual whatever his age and body weight. The glucose intolerance per se is due to, or accompagnied by various B cell dysfunctions according to its etiology. This is illustrated by the results observed in chronic pancreatitis, liver cirrhosis, aged or obese subjects.
通过研究静脉注射葡萄糖脉冲后120分钟再注射甲苯磺丁脲后的胰岛素反应，可以评估和计算人体胰岛素分泌的各种参数。B细胞对葡萄糖的相对不敏感性可能是遗传性胰腺易患糖尿病的标志，无论个体年龄和体重如何，均可在特定个体中进行评估。根据其病因，葡萄糖不耐受本身是由各种B细胞功能障碍引起的，或与之相伴。慢性胰腺炎、肝硬化、老年人或肥胖受试者的观察结果说明了这一点。
