早期肾脏疾病犬尿液酶的评估。

Evaluation of urinary enzymes in dogs with early renal disorder.

作者信息

Uechi M, Nogami Y, Terui H, Nakayama T, Ishikawa R, Wakao Y, Takahashi M

机构信息

Department of Veterinary Surgery, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.

出版信息

J Vet Med Sci. 1994 Jun;56(3):555-6. doi: 10.1292/jvms.56.555.

DOI:10.1292/jvms.56.555

PMID:7948390

Abstract

We investigated urinary N-acetyl-beta-D-glucosaminidase NAG (EC 3.2.1.30), gamma-glutamyl transpeptidase gamma-GTP (EC 2.3.2.2) and glycyl-prolyl dipeptidyl aminopeptidase GP-DAP (EC 3.4.14.5) in dogs with heartworm disease and renal failure. In the renal failure dogs, the NAG, gamma-GTP and GP-DAP index were significantly higher than those in the healthy dogs. In the heartworm disease dogs with normal chest X-rays (HW I), none of the enzyme values was significantly different from those of the healthy controls. In the dogs with heartworm disease showing abnormal heart shadows on their chest X-rays (HW II), enzyme values were significantly higher than those in the healthy dogs (P < 0.01) and the HW I dogs (P < 0.01). Thus, these urinary enzymes tests are available for the early detection of renal disorders.

摘要

我们对患有心丝虫病和肾衰竭的犬只的尿 N-乙酰-β-D-氨基葡萄糖苷酶（NAG，EC 3.2.1.30）、γ-谷氨酰转肽酶（γ-GTP，EC 2.3.2.2）和甘氨酰脯氨酰二肽氨基肽酶（GP-DAP，EC 3.4.14.5）进行了研究。在肾衰竭犬只中，NAG、γ-GTP 和 GP-DAP 指数显著高于健康犬只。在胸部 X 光片正常的心丝虫病犬只（HW I）中，酶值与健康对照组相比均无显著差异。在胸部 X 光片显示心脏阴影异常的心丝虫病犬只（HW II）中，酶值显著高于健康犬只（P < 0.01）和 HW I 犬只（P < 0.01）。因此，这些尿酶检测可用于早期发现肾脏疾病。