Markevich L N, Kolomiĭtseva I K
Biokhimiia. 1994 Jul;59(7):1027-33.
It has been shown that acute gamma-irradiation of rats with 100 Gy and 270 Gy doses when the lipid synthesis in the liver is activated, produces changes in the lipid content in liver cell organelles. The amount of cholesterol and its esters in the microsomal fraction increases after 100 Gy but decreases after 270 Gy irradiation, the phospholipid content being unchanged. In the mitochondrial fraction the lipid content decreases 1 hour after 270 Gy irradiation but is expressed in a lower degree after 48 hours. After the effect of continued gamma-irradiation with a daily dose of 0.129 Gy, the cholesterol and cardiolipid content in liver mitochondria increases. It is assumed that the changes in the lipid content in liver microsomes after acute gamma-irradiation are connected with activation of the synthetic function of the liver. Modification of the lipid content in the mitochondria after continued gamma-irradiation is suggestive of the role of cell energy metabolism in adaptation to gamma-irradiation.
