Lacro J P, Jeste D V
Department of Psychiatry, University of California, San Diego.
Biol Psychiatry. 1994 Aug 1;36(3):146-52. doi: 10.1016/0006-3223(94)91220-3.
We compared three groups of older psychiatric outpatients on numbers and types of physical illnesses and on number of nonpsychotropic medications. The subjects included 62 patients with Alzheimer's disease (AD), 41 with major depression (MD), and 78 with schizophrenia (SZ). The mean age in this predominantly male population was 68.4 years. Psychiatric diagnoses were based on DSM-III-R criteria. We utilized intake psychiatric assessments, chart reviews, and computerized pharmacy profiles to collect the data. The patients with SZ had significantly lower comorbidity compared to patients with MD, and had a significantly lower number of nonpsychotropic medications prescribed than both the AD and MD groups. These findings may reflect biological differences or may be secondary to differences in psychiatric treatment or in the use of health care resources. Alternatively, the low prevalence of physical comorbidity in SZ may represent a survivor or healthier cohort of patients.
我们比较了三组老年精神科门诊患者的躯体疾病数量及类型，以及非精神类药物的使用数量。研究对象包括62例阿尔茨海默病（AD）患者、41例重度抑郁症（MD）患者和78例精神分裂症（SZ）患者。在这个以男性为主的人群中，平均年龄为68.4岁。精神疾病诊断依据《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）标准。我们通过入院时的精神科评估、病历审查和电脑化药房记录来收集数据。与MD患者相比，SZ患者的合并症显著更少，且开具的非精神类药物数量明显低于AD组和MD组。这些发现可能反映了生物学差异，也可能是精神科治疗差异或医疗资源使用差异的继发结果。或者，SZ患者躯体合并症的低患病率可能代表了存活下来的患者或健康状况更佳的患者群体。
