Moldovan K M, Bajpai P K
University of Dayton, OH 45469-2320.
Biomed Sci Instrum. 1994;30:175-80.
This investigation was conducted to study the release of acetylsalicylic acid (ASA) from a beta-Tricalcium Phosphate (TCP) resorbable ceramic matrix (RCM) in Tris-HCl (pH 7.4, 0.5M) at 37 degrees C. Initial compression load studies were conducted for 12 hours. Compression load and dose-response studies were conducted for a total duration of seven days. Mixtures of 150 mg acetylsalicylic acid (Aspirin) and 500 mg TCP were compressed at loads of 2000, 3000, or 4000 lbs. Ceramics with 75, 150, 225, 300, or 375 mg of ASA were mixed with 500 mg TCP and compressed at 3000 lbs. Aliquots of Tris-HCl, taken at two hour intervals for the first 12 hours, and daily thereafter, were assayed spectrophotometrically for ASA at 245 nm. Differences in the amounts of ASA released by RCMs compressed at the three loads were not significant. Release of ASA from RCMs was linear only if the ceramic/ASA ratio was close to 6.67:1. Results of this investigation suggest that resorbable TCP ceramics can be used for continuous delivery of ASA for seven days.
本研究旨在研究乙酰水杨酸（ASA）在37℃下从β-磷酸三钙（TCP）可吸收陶瓷基质（RCM）中在Tris-HCl（pH 7.4，0.5M）中的释放情况。初始压缩负荷研究进行了12小时。压缩负荷和剂量反应研究总共进行了7天。将150毫克乙酰水杨酸（阿司匹林）和500毫克TCP的混合物在2000、3000或4000磅的负荷下压缩。将含有75、150、225、300或375毫克ASA的陶瓷与500毫克TCP混合，并在3000磅的负荷下压缩。在最初的12小时内，每隔两小时取一次Tris-HCl等分试样，此后每天取样，在245nm处用分光光度法测定ASA。在三种负荷下压缩的RCM释放的ASA量差异不显著。仅当陶瓷/ASA比率接近6.67:1时，RCM中ASA的释放才呈线性。本研究结果表明，可吸收的TCP陶瓷可用于连续7天递送ASA。
