Oliver C, Boudouresque F, Lacroix O, Anglade G, Grino M
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Institut Fédératif Jean Roche, Faculté de Médecine Nord, Marseille, France.
Endocr Regul. 1994 Jun;28(2):67-72.
During the stress hyporesponsive period (postnatal days 2-10), the stimulation of corticosterone secretion by ACTH is very low. In our study, we have observed that administration of ACTH during 3 consecutive days is followed by a striking increase in corticosterone response to an acute ACTH test. A comparable potentiation of corticosterone secretion was observed after a similar treatment with Lys gamma 3-MSH. The 3 day-treatment with each peptide induced an increase in adrenal weight. Similar data were obtained with alpha-MSH. However, corticosterone response to ACTH was not significantly altered following the same pattern of alpha-MSH administration.
在应激低反应期（出生后第2 - 10天），促肾上腺皮质激素（ACTH）对皮质酮分泌的刺激作用非常低。在我们的研究中，我们观察到连续3天给予ACTH后，皮质酮对急性ACTH试验的反应显著增加。用Lys γ 3 - MSH进行类似处理后，观察到皮质酮分泌有类似的增强作用。每种肽进行3天的处理均导致肾上腺重量增加。用α - MSH也获得了类似的数据。然而，按照相同的α - MSH给药模式，皮质酮对ACTH的反应没有显著改变。
