Wagner W, Grether U, Maar K, Jacobi E, Huth F
Res Exp Med (Berl). 1976 Dec 30;169(2):109-22. doi: 10.1007/BF01851172.
The effect of antiaggregating agents - acetylsalicyclic acid (ASA) and dipyridamol - on the rejection of allotransplanted canine kidneys in presensitized animals were studied. Blood flow dropped more markedly in the control group than in the group treated with ASA and dipyridamol. 24 hours after transplantation the blood flow in this group was significantly higher than in the control group (p 2,5 %) and in the third group treated with dipyridamol alone. The cellular rejection started earlier and was more pronounced in the control group. Only in this group vascular rejection and microthrombi were demonstrated. Urine output ceased 24 to 60 hours after transplantation. The immunosuppressive, antiphlogistic and platelet antiaggregating effect of the combined ASA and dipyridamol therapy is thought to be responsible for the better results in this group. In this experimental model the combined treatment of ASA and dipyridamol results in a later onset of cellular rejection, in better blood-flow of the kidney and later onset of anuria.
研究了抗聚集剂——乙酰水杨酸（ASA）和双嘧达莫——对致敏动物同种异体移植犬肾排斥反应的影响。对照组的血流下降比用ASA和双嘧达莫治疗的组更明显。移植后24小时，该组的血流明显高于对照组（p<0.025）以及仅用双嘧达莫治疗的第三组。细胞排斥反应在对照组开始得更早且更明显。仅在该组中出现了血管排斥反应和微血栓。移植后24至60小时尿量停止。ASA和双嘧达莫联合治疗的免疫抑制、抗炎和血小板抗聚集作用被认为是该组取得更好结果的原因。在这个实验模型中，ASA和双嘧达莫联合治疗导致细胞排斥反应延迟发生、肾脏血流改善以及无尿延迟出现。
