Zea-Iriarte W L, Ito M, Naito S, Nakayama T, Itsuno M, Fujii H, Furukawa M, Makiyama K, Sekine I
Department of Pathology, Nagasaki University School of Medicine.
Intern Med. 1994 Jul;33(7):422-6. doi: 10.2169/internalmedicine.33.422.
A 47-year-old man was admitted with appendicitis, and appendectomy was performed. On microscopic examination of the resected specimen, the presence of goblet cell carcinoid in the tip of appendix was revealed. This tumor showed an aggressive nature with perineural and vascular invasion around the appendiceal serosa. The tumor was composed of two main cell populations: mucin-producing (goblet cell type) and silver-positive cells (endocrine differentiation). Additionally, a few cells were also positive for serotonin and lysozyme, but negative for gastrin and ACTH. These findings suggest that goblet cell carcinoid share some functional and histologic characteristics with carcinoid tumors and adenocarcinomas, although it is a distinct entity.
一名47岁男性因阑尾炎入院并接受了阑尾切除术。对切除标本进行显微镜检查时，发现阑尾尖端存在杯状细胞类癌。该肿瘤具有侵袭性，在阑尾浆膜周围有神经周围和血管侵犯。肿瘤由两种主要细胞群组成：产生黏液的（杯状细胞型）和嗜银阳性细胞（内分泌分化）。此外，少数细胞对5-羟色胺和溶菌酶也呈阳性，但对胃泌素和促肾上腺皮质激素呈阴性。这些发现表明，尽管杯状细胞类癌是一种独特的实体，但它与类癌肿瘤和腺癌有一些功能和组织学特征相同。
