Suda T, Sato A, Toyoshima M, Imokawa S, Yoshitomi A, Tamura R, Suganuma H, Yagi T, Hayakawa H, Shirai M
Department of Internal Medicine, Hamamatsu University School of Medicine.
Intern Med. 1994 Jul;33(7):437-40. doi: 10.2169/internalmedicine.33.437.
Low-dose methotrexate therapy has been used to treat a variety of chronic inflammatory diseases; a few studies have discussed the efficacy of this therapy for sarcoidosis. We present a patient with symptomatic sarcoidosis who was successfully treated with low-dose methotrexate after being refractory to steroids. This patient showed significant clinical improvement without development of any severe side effects. These findings suggest that low-dose methotrexate therapy may be a useful alternative treatment for sarcoidosis.
低剂量甲氨蝶呤疗法已被用于治疗多种慢性炎症性疾病；一些研究讨论了该疗法对结节病的疗效。我们报告一例有症状的结节病患者，该患者在对类固醇治疗无效后，接受低剂量甲氨蝶呤治疗取得成功。该患者临床症状显著改善，且未出现任何严重副作用。这些发现表明，低剂量甲氨蝶呤疗法可能是结节病一种有用的替代治疗方法。
