Björkholm M, Holm G, Mellstedt H, Carlberger G, Nisell J
Scand J Haematol. 1976 Nov;17(5):341-6. doi: 10.1111/j.1600-0609.1976.tb01444.x.
A case of pure red cell aplasia appearing 6 months following thymectomy is reported in a 43-year-old man. Immunofluorescence studies of the patient's bone marrow have demonstrated the presence of membrane-bound IgG on the majority of erythroblasts and some mature erythrocytes. It is suggested that the IgG represents anti-erythroid autoantibodies. The number of Ig-bearing lymphocytes in peripheral blood was decreased as was the level of immunoglobulins indicating a B-lymphocyte deficiency. T-lymphocyte functions were without remarks. The patient was initially treated with corticosteroids and oxymetholone. He responded well to this therapy but relapsed 9 month later. Cyclophosphamide treatment was started and followed by a complete haematologic remission.
本文报道了一例43岁男性患者，在胸腺切除术后6个月出现纯红细胞再生障碍性贫血。对该患者骨髓进行的免疫荧光研究显示，大多数成红细胞和一些成熟红细胞上存在膜结合IgG。提示该IgG代表抗红细胞自身抗体。外周血中含Ig淋巴细胞数量减少，免疫球蛋白水平也降低，提示B淋巴细胞缺乏。T淋巴细胞功能无异常。患者最初接受皮质类固醇和羟甲烯龙治疗。他对该治疗反应良好，但9个月后复发。开始使用环磷酰胺治疗，随后实现了完全血液学缓解。
