模拟皮质扩散性抑制
Modeling cortical spreading depression.
作者信息
Reggia J A, Montgomery D
机构信息
Dept. of Computer Science, University of Maryland, College Park 20742.
出版信息
Proc Annu Symp Comput Appl Med Care. 1994:873-7.
Cortical spreading depression is a wave of electrical silence and biochemical changes that spreads across the cerebral cortex. Recently there has been a growing recognition that it may be an important pathophysiological event in a number of neurological disorders. In this paper, we describe a reaction-diffusion model of the extracellular potassium changes that are a central part of this process. Simulations with the model show that an appropriate stimulus evokes a moving wave of increased potassium with many similarities to that seen experimentally. The resultant model is a useful computational tool for future study of the effects of spreading depression on the cortex.
皮层扩散性抑制是一种电沉默和生化变化的波，它在大脑皮层中传播。最近，人们越来越认识到它可能是许多神经系统疾病中一个重要的病理生理事件。在本文中，我们描述了作为这一过程核心部分的细胞外钾变化的反应扩散模型。用该模型进行的模拟表明，适当的刺激会引发钾增加的移动波，与实验中观察到的情况有许多相似之处。由此产生的模型是未来研究扩散性抑制对皮层影响的一个有用的计算工具。
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