Mery C, Delrieu F, Ghozlan R, Saporta L, Simon F, Amor B, Menkes C J, Delbarre F
Scand J Rheumatol. 1976;5(4):241-7. doi: 10.3109/03009747609099913.
The findings are reported of a controlled clinical trial comparing in 66 rheumatoid arthritis patients 0 g (placebo), and 0.50 g a day and 1 g a day of penicillamine. Each of these groups has been subdivided into two, one part receiving 5 mg a day of zinc metal supplement, the other a placebo. The trial was planned to be double-blind, and for each patient to take part for 4 months. The results prove the effectiveness of penicillamine in rheumatoid arthritis. 0.50 g a day has the same effect as 1 g a day but gives less side effects. Zinc supplement inhibits the clinical effects of penicillamine but does not prevent the side effects.
报告了一项对照临床试验的结果，该试验在66名类风湿性关节炎患者中比较了0克（安慰剂）、每日0.50克和每日1克青霉胺的疗效。每组又分为两部分，一部分每天服用5毫克锌补充剂，另一部分服用安慰剂。该试验计划为双盲试验，每位患者参与4个月。结果证明青霉胺对类风湿性关节炎有效。每日0.50克与每日1克效果相同，但副作用较少。补充锌会抑制青霉胺的临床疗效，但不能预防副作用。
