秀丽隐杆线虫外阴发育过程中的信号转导与细胞命运特化
Signal transduction and cell fate specification during Caenorhabditis elegans vulval development.
作者信息
Eisenmann D M, Kim S K
机构信息
Department of Developmental Biology, Beckman Center, Stanford University Medical Center, California 94305.
出版信息
Curr Opin Genet Dev. 1994 Aug;4(4):508-16. doi: 10.1016/0959-437x(94)90065-b.
A receptor tyrosine kinase/Ras signaling pathway controls the specification of vulval cell fates in Caenorhabditis elegans. Recently, C. elegans genes encoding proteins with similarity to mammalian Raf (lin-45), mitogen-activated protein kinase (mpk-1/sur-1), and an HNF-3 transcription factor (lin-31) have been identified and shown to act downstream of let-60 (ras) in this pathway. These genetically identified gene products bridge the gap between signal transduction at the plasma membrane and the control of cell fate specification in the nucleus.
受体酪氨酸激酶/Ras信号通路控制着秀丽隐杆线虫中外阴细胞命运的特化。最近，已鉴定出编码与哺乳动物Raf（lin-45）、丝裂原活化蛋白激酶（mpk-1/sur-1）和HNF-3转录因子（lin-31）相似的蛋白质的秀丽隐杆线虫基因，并表明它们在该信号通路中位于let-60（ras）的下游发挥作用。这些通过遗传学鉴定的基因产物填补了质膜上信号转导与细胞核中细胞命运特化控制之间的空白。
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