Bidon J C, Blin M, Gogny M, Vu A T, Jondet A
Laboratoire de Physiologie et Pharmacodynamie, Institut national de la Recherche agronomique, Ecole nationale vétérinaire, Nantes, France.
Int Arch Allergy Immunol. 1994 May;104(1):72-8. doi: 10.1159/000236711.
Changes in the reactivity of the ileum (to histamine and barium chloride) and vas deferens (to acetylcholine and barium chloride), isolated from actively egg albumen-sensitized guinea pigs, have been investigated. The study was performed on 2 guinea pig strains: the Dunkin-Hartley strain, usually used as an airway allergic model, and the BFA strain. In actively sensitized guinea pigs of both strains, concentration-response curves exhibited a significant dose-dependent upward shift compared to those obtained in control guinea pigs. The maximal contraction strength calculated from these curves was significantly enhanced in both sensitized guinea pig strains, without a change in EC50 values. This study showed that the active antigen sensitization procedure involved several smooth muscle functions, and not exclusively the trachea.
对从主动致敏于蛋清的豚鼠分离出的回肠（对组胺和氯化钡）及输精管（对乙酰胆碱和氯化钡）的反应性变化进行了研究。该研究在两种豚鼠品系上进行：通常用作气道过敏模型的Dunkin-Hartley品系和BFA品系。在两种品系的主动致敏豚鼠中，与对照豚鼠相比，浓度-反应曲线呈现出显著的剂量依赖性向上偏移。从这些曲线计算出的最大收缩强度在两种致敏豚鼠品系中均显著增强，而EC50值无变化。本研究表明，主动抗原致敏过程涉及多种平滑肌功能，而非仅涉及气管。
