Anastasatu C, Anastasatu O, Murgoci G, Dobre M
Institutul de Pneumoftiziologie Marius Nasta, Bucureşti.
Pneumoftiziologia. 1993 Oct-Dec;42(4):9-12.
The short-course chemotherapy (9 months) in the severe forms of tuberculosis in children is a very modern item. It was very few approached on an international level and relatively short time ago in our country. There were applied the following therapeutical regimens: 3 HRZ2 6 HR2 (in the experimental group) and 3 HR/3 HR2/6 H2 (in the control group). In the granulias and the caseous forms the late results, at 5 years after treatment end, were very good in 100% of cases in both groups. In meningitis clinical very good results (without sequellae) presented a proportion of 70.1% in the experimental group and of 68.2% in the control group (difference statistically non significant). The main advantage of the intensive short course regimens (9 months) comparatively with the "classical" ones (of at least 12 months) consists in reaching finally the same good results but in at least 3 months shorter time interval.
儿童重症结核病的短程化疗（9个月）是一项非常现代的项目。在国际上，这方面的研究很少，在我国也是相对较新的。采用了以下治疗方案：3HRZ2 6HR2（实验组）和3HR/3HR2/6H2（对照组）。在结节状和干酪样病变形式中，治疗结束5年后的远期结果在两组100%的病例中都非常好。在脑膜炎方面，实验组临床效果非常好（无后遗症）的比例为70.1%，对照组为68.2%（差异无统计学意义）。与“经典”方案（至少12个月）相比，强化短程方案（9个月）的主要优势在于最终能取得同样好的效果，但时间间隔至少短3个月。
