Davydova S A, Murashev A N, Medvedev O S
Eksp Klin Farmakol. 1994 Jul-Aug;57(4):21-4.
The effects of endothelin (0.1 nMol/kg and 1 nMol/kg into the left ventricle) on hemodynamics and cardiac contractility were investigated in conscious and unrestrained, WKY rats before and during continuous infusion of atriopeptides (1 microgram/kg/min i.v.). Bolus injection on endothelin into the left ventricle caused a transient hypotension and tachycardia followed by a long-lasting increase in mean blood pressure (MBP) and bradycardia in intact rats. In the rats receiving constant atriopeptide infusions, the hypotensive phase of endothelin effects was augmented whereas the hypertensive phase was reduced. Endothelin doses dependently increased cardiac contractility parameters during the first 3 minutes after injection. The stimulation of cardiac function at this time resulted from reflex responses due to the rapid decrease in the MBP. These effects were followed by decreases in cardiac contractility indices. Infusion of atriopeptide led to a tendency to the positive inotropic action of and augmented the negative inotropic action of endothelin.
在清醒且不受束缚的WKY大鼠中，于持续输注心房肽（1微克/千克/分钟，静脉注射）之前及期间，研究了内皮素（分别以0.1纳摩尔/千克和1纳摩尔/千克的剂量注入左心室）对血流动力学和心脏收缩性的影响。向完整大鼠的左心室一次性注射内皮素会导致短暂的低血压和心动过速，随后平均血压（MBP）出现持久升高以及心动过缓。在持续输注心房肽的大鼠中，内皮素作用的低血压期增强，而高血压期减弱。注射后最初3分钟内，内皮素剂量依赖性地增加心脏收缩性参数。此时心脏功能的刺激是由于MBP迅速下降引起的反射反应。这些作用之后是心脏收缩性指标的下降。输注心房肽导致内皮素出现正性肌力作用的趋势，并增强了其负性肌力作用。
