Bardamova I B, Afanas'ev S A
Eksp Klin Farmakol. 1994 Jul-Aug;57(4):29-31.
The interaction of the cAMP-phosphodiesterase inhibitor milrinone and the beta-adrenoceptor agonist isoproterenol was studied on guinea-pig isolated hearts. Milrinone, (10 microns) caused a positive inotropic response which differed from that of isoproterenol (7 nM) and decreased cardiac inotropic responses to the subsequent administration of isadrin despite a significant great rise in cAMP. The interaction of the drugs is assumed to be associated with the milrinone-induced increase in cGMP which is able to restrict myocardial cAMP-activated processes.
在豚鼠离体心脏上研究了环磷腺苷磷酸二酯酶抑制剂米力农与β-肾上腺素能受体激动剂异丙肾上腺素的相互作用。米力农（10微摩尔）引起正性肌力反应，该反应与异丙肾上腺素（7纳摩尔）不同，尽管环磷腺苷显著大幅升高，但米力农降低了心脏对随后给予异他林的肌力反应。推测药物之间的相互作用与米力农诱导的环鸟苷酸增加有关，环鸟苷酸能够限制心肌中环磷腺苷激活的过程。
