[抗心绞痛治疗耐药性的时间生物学方面]
[The chronobiological aspects of drug resistance to antianginal therapy].
作者信息
Arushanian E B, Shamliian T A
出版信息
Eksp Klin Farmakol. 1994 Jul-Aug;57(4):33-5.
PMID:7950781
Abstract
Two groups of ischemic heart disease patients with different responses to antianginal therapy (propranolol, nifedipine) were studied. Mathematical analysis of heart rate variabilities showed that tolerant patients had a low index of centralization, lack of its circadian rhythm and a low correlation between several cardiointervalographic parameters. Bearing in mind these shifts makes it possible to predict the therapeutical efficiency of the antianginal drugs.
摘要
对两组对抗心绞痛治疗（普萘洛尔、硝苯地平）有不同反应的缺血性心脏病患者进行了研究。心率变异性的数学分析表明，耐受性患者的集中指数较低，缺乏昼夜节律，且几个心动间期参数之间的相关性较低。记住这些变化有助于预测抗心绞痛药物的治疗效果。
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