Drozd N N, Sher A I, Makarov V A, Gal'braĭkh L S, Vikhoreva G A, Gorbacheva I N
Eksp Klin Farmakol. 1994 Jul-Aug;57(4):42-5.
Rabbit experiments have revealed that there is a relationship between the chemical structure and anticoagulative effects of polysulfated chitosan derivatives. Sixteen chitosan polymers with a polarization rate of 71 to 547 and substitution by sulfur from 0.62 to 1.86 which were intravenously injected showed heparin-like action. The anticoagulant activity of chitosan samples depended on the degrees of polymerization and sulfation. The most active (30-52 U/mg) and long-acting (250-350 min) products had a polymerization in the range 180-240 and sulfation no less than 1.5, the half-life being 37-50 min, and the elimination constant being 1.38.10(-2) to 1.88.10(-2)min-1.
兔子实验表明，多硫酸化壳聚糖衍生物的化学结构与其抗凝作用之间存在关联。静脉注射的16种极化率为71至547且硫取代度为0.62至1.86的壳聚糖聚合物表现出类肝素作用。壳聚糖样品的抗凝活性取决于聚合度和硫酸化程度。活性最高（30 - 52 U/mg）且作用时间最长（250 - 350分钟）的产品聚合度在180 - 240范围内，硫酸化程度不低于1.5，半衰期为37 - 50分钟，消除常数为1.38×10⁻²至1.88×10⁻²分钟⁻¹。
