Penzo M, Palatini P, Rossi G P, Zanin L, Pessina A C
Department of Clinical Medicine, University of Padua, Italy.
Clin Exp Hypertens. 1994 Sep;16(5):659-73. doi: 10.3109/10641969409067967.
To investigate whether the 24-hour blood pressure (BP) profile of primary aldosteronism differs from that of primary hypertension, ambulatory BP monitoring was performed in 11 patients with primary aldosteronism (9 with an adrenal adenoma and 2 with idiopathic hyperaldosteronism) and in 11 primary hypertensives, matched for sex (5M,6F), age (mean: 52 vs 49 yrs) and casual BP. We found no difference in 24-hour BP, nocturnal BP fall, BP variability (standard deviation and peaks of pressure) response to postural changes (lying-standing BP) between the two groups (all p values n.s.). Within the patients with primary aldosteronism no correlation was observed between BP, plasma renin activity, blood and urine aldosterone levels, blood and urine K+, and size of the tumour. Thus, at variance with previous reports, these results show that diurnal rhythm of BP and BP variability are similar in primary aldosteronism and primary hypertensives with similar demographic features and causal BP levels. They also show that an orthostatic fall of BP is not a common feature in this disease.
为研究原发性醛固酮增多症患者的24小时血压（BP）情况是否与原发性高血压患者不同，我们对11例原发性醛固酮增多症患者（9例肾上腺腺瘤患者和2例特发性醛固酮增多症患者）以及11例原发性高血压患者进行了动态血压监测，两组患者在性别（5男，6女）、年龄（平均：52岁对49岁）和偶测血压方面相匹配。我们发现两组患者在24小时血压、夜间血压下降、血压变异性（标准差和压力峰值）以及体位变化（平卧位 - 站立位血压）反应方面均无差异（所有p值均无统计学意义）。在原发性醛固酮增多症患者中，未观察到血压、血浆肾素活性、血和尿醛固酮水平、血和尿钾离子以及肿瘤大小之间存在相关性。因此，与之前的报道不同，这些结果表明，在具有相似人口统计学特征和偶测血压水平的原发性醛固酮增多症患者和原发性高血压患者中，血压的昼夜节律和血压变异性相似。这些结果还表明，体位性血压下降在该疾病中并非常见特征。
