Joseph J, Scopelitis E
Department of Medicine, LSU Medical Center, New Orleans 70112.
Lupus. 1994 Jun;3(3):201-3. doi: 10.1177/096120339400300312.
Antiphospholipid syndrome is characterized by thrombosis, recurrent fetal loss, thrombocytopenia and is associated with the presence of antiphospholipid antibodies, especially anticardiolipin antibodies. We present a patient with the clinical features of antiphospholipid syndrome, namely recurrent venous and arterial thrombosis, recurrent abortions, thrombocytopenia and libido reticularis but with persistently negative serology for any type of antiphospholipid antibody. The possible existence of 'seronegative' antiphospholipid syndrome is proposed. Of additional interest in this patient is the presence of significantly elevated levels of plasminogen activator inhibitor. The role of this inhibitor, if any, in the antiphospholipid syndrome and/or seronegative antiphospholipid syndrome is not known and merits further study.
抗磷脂综合征的特征为血栓形成、反复流产、血小板减少，并与抗磷脂抗体尤其是抗心磷脂抗体的存在有关。我们报告一例具有抗磷脂综合征临床特征的患者，即反复静脉和动脉血栓形成、反复流产、血小板减少及网状青斑，但所有类型抗磷脂抗体的血清学检查持续呈阴性。本文提出了“血清阴性”抗磷脂综合征可能存在的观点。该患者另一个值得关注的问题是血浆纤溶酶原激活物抑制剂水平显著升高。这种抑制剂在抗磷脂综合征和/或血清阴性抗磷脂综合征中（如果有作用的话）的作用尚不清楚，值得进一步研究。
