Piha S J, Rönnemaa T, Koskenvuo M
Social Insurance Institution, Research Centre, Turku, Finland.
Int J Obes Relat Metab Disord. 1994 Aug;18(8):547-50.
In order to study influence of moderate obesity on autonomic nervous function, nineteen identical twin pairs were studied by standard non-invasive cardiovascular reflex tests and pupillometry. There had to be a difference in Body Mass Index (BMI) of at least 3 kg/m2 between the twins. The mean +/- s.d. BMI was 30 +/- 2 and 23 +/- 1 kg/m2 in obese and non-obese individuals, respectively. All of the participants were healthy and they did not use any drugs known to affect autonomic function. No significant differences were found in any of the heart rate, blood pressure, or pupillary responses between obese and non-obese twins. A strong correlation between lean and obese pairs was found in most autonomic variables reflecting parasympathetic function and in some reflecting sympathetic function. It is concluded that (1) neither sympathetic nor parasympathetic responsiveness is affected significantly by moderate obesity and (2) genetic factors play an essential role in determining the cardiovascular autonomic reactivity.
为了研究中度肥胖对自主神经功能的影响，通过标准非侵入性心血管反射测试和瞳孔测量法对19对同卵双胞胎进行了研究。双胞胎之间的体重指数（BMI）必须至少相差3 kg/m²。肥胖个体和非肥胖个体的平均±标准差BMI分别为30±2和23±1 kg/m²。所有参与者均健康，且未使用任何已知会影响自主神经功能的药物。在肥胖双胞胎和非肥胖双胞胎之间，未发现心率、血压或瞳孔反应存在任何显著差异。在反映副交感神经功能的大多数自主神经变量以及一些反映交感神经功能的变量中，发现瘦体型双胞胎和肥胖双胞胎之间存在很强的相关性。得出的结论是：（1）中度肥胖对交感神经和副交感神经反应性均无显著影响；（2）遗传因素在决定心血管自主反应性方面起着至关重要的作用。
