Labbate L A, Pollack M H
Walter Reed Army Medical Center, Department of Psychiatry, Washington, D.C. 20307.
Ann Clin Psychiatry. 1994 Mar;6(1):13-5. doi: 10.3109/10401239409148833.
Antidepressant-induced sexual dysfunction is a common and significant cause of patient distress and noncompliance with treatment. A number of adjunctive pharmacologic strategies, including yohimbine, cyproheptadine, bethanechol, and amantadine, have been employed previously. We report a case of using bupropion to treat fluoxetine-induced sexual dysfunction in a 50-year-old man with a history of recurrent major depression. This is the first case of such treatment we know. Sexual dysfunction induced by fluoxetine is thought secondary to effects on the serotonin system. Bupropion is an antidepressant with minimal sexual side effects. The mechanism by which bupropion resolved this sexual dysfunction is unknown, but it may be related to its mild dopamine uptake blockade.
抗抑郁药引起的性功能障碍是导致患者痛苦和治疗依从性差的常见且重要原因。此前已采用多种辅助药物治疗策略，包括育亨宾、赛庚啶、氨甲酰甲胆碱和金刚烷胺。我们报告了一例使用安非他酮治疗一名有复发性重度抑郁症病史的50岁男性因氟西汀引起的性功能障碍的病例。这是我们所知的首例此类治疗病例。氟西汀引起的性功能障碍被认为是对5-羟色胺系统产生作用的继发结果。安非他酮是一种几乎没有性副作用的抗抑郁药。安非他酮解决这种性功能障碍的机制尚不清楚，但可能与其对多巴胺摄取的轻度阻断作用有关。
